Lab test

Treponemal Syphilis Test

This treponemal test checks the blood for antibodies that specifically target Treponema pallidum, the bacterium that causes syphilis.

Typical price

From $198

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

This treponemal test checks the blood for antibodies that specifically target Treponema pallidum, the bacterium that causes syphilis. Because it is pathogen-specific, it is often used to confirm a reactive nontreponemal screen or as an initial screening test depending on the testing approach. Once positive, treponemal antibodies can remain detectable for a long time, so the result is interpreted together with other tests and clinical history.

• Treponema pallidum antibodies Antibodies directed specifically against the bacterium that causes syphilis.

• You have symptoms or possible exposure to syphilis.
• A prior screening test was reactive and needs confirmation.
• You are being screened for sexually transmitted infections.
• A clinician is evaluating your syphilis status.

• No fasting is required for this blood test.
• The sample can be collected at any time of day.
• Tell the clinician about any previous syphilis diagnosis or treatment.
• Report other conditions that might affect antibody results.

A positive treponemal result indicates antibodies against Treponema pallidum are present, which may reflect current or past infection. Because these antibodies can persist after treatment, a positive result alone does not prove active infection; a nontreponemal test and clinical evaluation help clarify. A negative result generally argues against syphilis but can occur very early after exposure. Discuss the interpretation with a healthcare provider.

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