Lab test

RPR Test (Syphilis) - Rapid Plasma Reagin

The rapid plasma reagin (RPR) test is a blood test used to screen for syphilis by detecting antibodies associated with the infection.

Typical price

From $49

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

The rapid plasma reagin (RPR) test is a blood test used to screen for syphilis by detecting antibodies associated with the infection. It is a nontreponemal test, meaning it measures antibodies that can also appear in some other conditions, so a positive screening result is usually followed by a more specific treponemal test. RPR results can also be used to follow response to treatment over time.

• Rapid plasma reagin (RPR) Nontreponemal antibodies detected in blood that are associated with syphilis infection.

• You have symptoms or possible exposure to syphilis.
• You are due for routine STI screening.
• A partner has been diagnosed with syphilis.
• A clinician wants to monitor response to prior syphilis treatment.

• No fasting is required for this blood test.
• The sample can be collected at any time of day.
• Tell the clinician about any prior syphilis diagnosis or treatment.
• Report conditions or medications that might affect antibody testing.

A positive RPR result suggests possible syphilis and is usually confirmed with a treponemal-specific test because the RPR can be positive in other situations. A negative result generally argues against active syphilis, though very early infection can be missed. RPR levels may be tracked over time to assess treatment response. Discuss any result and the need for confirmation with a healthcare provider.

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