Lab test

Alpha-Fetoprotein (AFP) Tumor Marker Test

The alpha-fetoprotein (AFP) tumor marker test measures AFP, a protein normally produced by the fetal liver and yolk sac and present only at low levels after birth.

Typical price

From $44

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

The alpha-fetoprotein (AFP) tumor marker test measures AFP, a protein normally produced by the fetal liver and yolk sac and present only at low levels after birth. Certain tumors, including liver cancer and germ cell tumors of the testis or ovary, can raise AFP levels, and chronic liver disease can also increase it. The test is used to support diagnosis and especially to monitor response to treatment and detect recurrence. It is interpreted together with imaging and other findings.

• Alpha-Fetoprotein (AFP) A protein measured in blood that can be elevated in certain liver and germ cell tumors.

• People with known or suspected liver cancer
• Individuals with a germ cell tumor being monitored
• Patients at high risk of liver cancer undergoing surveillance
• People being followed after treatment for an AFP-producing tumor

• No fasting is usually required
• Report any pregnancy, liver disease, or recent treatment
• Tell the phlebotomist about medications and conditions affecting the liver
• Follow any specific instructions included with your order

A high AFP level can occur with liver cancer, germ cell tumors, or liver disease, and it is also normally elevated during pregnancy. Because it is not specific to one condition, AFP is interpreted with imaging, other tumor markers, and clinical findings. A normal level does not exclude cancer, and levels are often tracked over time. Discuss your AFP result and what it may mean with a healthcare provider.

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