Lab test

Pregnenolone Test

This blood test measures pregnenolone, a hormone that serves as the starting material for the body's production of many other steroid hormones.

Typical price

From $175

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

This blood test measures pregnenolone, a hormone that serves as the starting material for the body's production of many other steroid hormones. Pregnenolone is made mainly in the adrenal glands and, in smaller amounts, in the gonads and brain, and it is converted into hormones such as progesterone, DHEA, and cortisol. Because it sits near the beginning of the steroid pathway, it can be measured when a healthcare provider wants to assess steroid hormone production. The test is typically interpreted alongside related hormones rather than alone. Results are considered with age, sex, symptoms, and the wider clinical picture.

• Pregnenolone A precursor hormone used by the body to make other steroid hormones.

• People being evaluated for steroid hormone production
• Individuals with symptoms that may involve adrenal or gonadal hormones
• Those whose provider wants a fuller picture of the steroid pathway
• People with suspected hormone-related conditions under investigation

• Morning collection is often preferred because steroid hormones vary through the day; follow your provider's timing
• Report all hormone or steroid medications and supplements to the laboratory
• Follow any additional instructions that come with your order

Pregnenolone is compared against reference ranges that vary with age and sex. Because it is a precursor rather than a final hormone, an abnormal value is usually interpreted with progesterone, DHEA, cortisol, and other steroid hormones to understand the pathway. Levels can be influenced by medications and supplements. A healthcare provider should assess the result with your symptoms and any additional testing before drawing conclusions.

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