Lab test

Mono Test (Mononucleosis) - Blood Testing

A mononucleosis test helps evaluate for infectious mononucleosis, an illness often caused by the Epstein-Barr virus (EBV).

Typical price

From $49

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

A mononucleosis test helps evaluate for infectious mononucleosis, an illness often caused by the Epstein-Barr virus (EBV). It may use a heterophile antibody screen, sometimes called a monospot, and EBV-specific antibodies to distinguish a current infection from a past one. Clinicians order it for persistent sore throat, fever, swollen lymph nodes, and fatigue that suggest mono.

• Heterophile antibody (monospot) A rapid screen for antibodies often produced during infectious mononucleosis.
• EBV viral capsid antigen (VCA) IgM Can indicate a recent EBV infection.
• EBV viral capsid antigen (VCA) IgG Can indicate current or past EBV infection.
• EBV nuclear antigen (EBNA) IgG Usually appears later and suggests a past infection.

• People with a sore throat that lasts longer than expected.
• Individuals with fever, fatigue, and swollen lymph nodes.
• Those with an enlarged spleen or unusual tiredness.
• People with a rash and systemic symptoms.
• Anyone whose symptoms suggest EBV infection.

• No fasting is required for mono testing.
• Take usual medications unless told otherwise.
• Tell the provider how long symptoms have lasted.
• A standard blood draw is used for antibody tests.
• Timing can affect results, so share symptom history.

A reactive heterophile or EBV VCA IgM result can support a recent EBV infection, while VCA IgG with EBNA IgG often reflects a past infection. Early testing may be negative before antibodies develop, so repeat testing can be needed. Mono is usually a clinical diagnosis supported by lab markers. Discuss the results with a healthcare provider.

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