Lab test

Methylmalonic Acid Blood Test

The methylmalonic acid (MMA) blood test measures a substance produced during metabolism that rises when vitamin B12 is deficient.

Typical price

From $198

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

The methylmalonic acid (MMA) blood test measures a substance produced during metabolism that rises when vitamin B12 is deficient. Because MMA is more sensitive than vitamin B12 alone, it is used to confirm a suspected deficiency, especially when the B12 level is borderline or when symptoms suggest a problem. It can also be elevated in kidney disease. The test helps evaluate causes of anemia, fatigue, and nerve symptoms and is interpreted with your B12 level and clinical picture.

• Methylmalonic Acid (MMA) A metabolic byproduct that accumulates when vitamin B12 is insufficient.

• People with symptoms or blood tests suggesting vitamin B12 deficiency
• Individuals with unexplained anemia or fatigue
• Patients with numbness, tingling, or other nerve symptoms
• People at risk of low B12 such as those with restricted diets or on certain medications

• Fasting may be requested; follow the instructions included with your order
• Report all vitamin B12 supplements and injections
• Tell the phlebotomist about kidney disease, which can raise MMA
• Follow any medication instructions provided

A high MMA level supports vitamin B12 deficiency, even when the B12 level itself is borderline, and can help explain anemia or nerve symptoms. However, kidney disease can also raise MMA, so results are interpreted with kidney function and other tests. A normal MMA generally makes significant B12 deficiency less likely. Discuss your MMA result and what it means for you with a healthcare provider.

• Alabama
• Alaska
• Arizona
• Arkansas
• California
• Colorado
• Connecticut
• Delaware
• Florida
• Georgia