Lab test

Lupus Panel

A lupus panel groups blood tests that can support evaluation of lupus, an autoimmune condition that can affect the skin, joints, kidneys, and other organs.

Typical price

From $249

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

A lupus panel groups blood tests that can support evaluation of lupus, an autoimmune condition that can affect the skin, joints, kidneys, and other organs. It commonly includes antinuclear antibodies, anti-dsDNA, anti-Smith, anti-RNP, anti-Ro/SSA, anti-La/SSB, and complement proteins C3 and C4. Clinicians order it when symptoms such as rashes, joint pain, or unexplained fatigue raise concern for lupus.

• Antinuclear antibodies (ANA) A screening autoantibody often positive in lupus.
• Anti-double-stranded DNA (anti-dsDNA) An autoantibody that can be associated with lupus activity.
• Anti-Smith (anti-Sm) An autoantibody relatively specific to lupus.
• Anti-RNP An autoantibody that can occur in lupus and related conditions.
• Anti-Ro/SSA An autoantibody that can occur in lupus and related conditions.
• Anti-La/SSB An autoantibody that can occur in lupus and related conditions.
• Complement C3 A complement protein that can fall with immune activity.
• Complement C4 A complement protein that can fall with immune activity.

• People with unexplained rashes, especially sun-sensitive ones.
• Individuals with persistent joint pain or swelling.
• Those with unexplained fever, fatigue, or organ symptoms.
• People with a family history of lupus or autoimmune disease.
• Anyone whose provider suspects lupus.

• No fasting is required for lupus antibody testing.
• Take usual medications unless told otherwise.
• Tell the provider about symptoms, their duration, and medications.
• A standard blood draw is used for the samples.
• Be prepared to provide a full health and family history.

A positive ANA is common in lupus but can occur without disease, so more specific antibodies such as anti-dsDNA and anti-Sm help refine the picture. Anti-Ro/SSA and anti-La/SSB can accompany certain symptoms, and low complement C3 or C4 can be associated with immune activity. No single marker confirms lupus. Discuss results with a healthcare provider.

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