Lab test

HIV 4th Generation Antigen/Antibody Test

The HIV 4th generation antigen/antibody test, often called a DUO test, detects both HIV antibodies and the p24 antigen in a single blood sample.

Typical price

From $49

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

The HIV 4th generation antigen/antibody test, often called a DUO test, detects both HIV antibodies and the p24 antigen in a single blood sample. Because p24 antigen appears earlier than antibodies in many infections, this test can shorten the window between exposure and detection compared with older antibody-only tests. It is a standard screening tool for HIV and results are confirmed with additional testing when needed.

• HIV antibodies Antibodies the immune system produces in response to HIV types 1 and 2.
• HIV p24 antigen A viral protein that can appear in the blood early after infection, before antibodies develop.

• You want routine HIV screening.
• You had a possible exposure and want a test that detects early infection.
• A clinician is evaluating symptoms that could relate to HIV.
• You are being screened as part of sexual health care.

• No fasting is required for this blood test.
• The sample can be collected at any time of day.
• Tell the clinician about the timing of any possible exposure.
• Report prevention medications such as HIV pre-exposure prophylaxis.

A negative result means antibodies and p24 antigen were not detected, though a very recent exposure might still be too early for detection and repeat testing may be advised. A positive result indicates that HIV antibodies or p24 antigen were found and requires confirmatory testing and prompt clinical follow-up. The DUO test is a screening tool, not a diagnosis by itself. Discuss results with a healthcare provider.

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