Lab test

Aldosterone-to-Renin Ratio Test - Lab Test

The aldosterone-to-renin ratio compares two hormones that regulate blood pressure and salt balance.

Typical price

From $149

Results

1-3 business days

Preparation

See preparation notes below

Sample

Blood draw or sample collection at a local center

The aldosterone-to-renin ratio compares two hormones that regulate blood pressure and salt balance. Aldosterone signals the kidneys to retain sodium and water, while renin is released by the kidneys and controls aldosterone production. Calculating the ratio helps screen for primary aldosteronism, a condition in which the adrenal glands make too much aldosterone despite low renin, causing high blood pressure and sometimes low potassium. The test is often requested for difficult-to-control hypertension, early-onset hypertension, or an adrenal nodule.

• Aldosterone A hormone from the adrenal glands that promotes sodium retention and raises blood pressure.
• Renin A kidney enzyme that normally regulates aldosterone; low renin with high aldosterone is the key finding in primary aldosteronism.
• Aldosterone-to-Renin Ratio (ARR) The calculated ratio used to screen for inappropriate aldosterone production.

• People with high blood pressure that is difficult to control
• Individuals with high blood pressure and low potassium
• People with an adrenal nodule found on imaging
• Those with early-onset high blood pressure or a family history of it

• Collect the sample in the morning, often after sitting or standing as instructed
• Your provider may adjust salt intake or medications before testing; never change medicines on your own
• Avoid licorice and medications that affect the renin-angiotensin system unless cleared by your provider
• Correct potassium levels if advised before the draw

A high aldosterone-to-renin ratio can indicate primary aldosteronism, where aldosterone is inappropriately high relative to suppressed renin. A normal ratio does not fully exclude the condition, and confirmatory testing may follow. Many medications, potassium levels, and salt intake influence both hormones, so results must be interpreted carefully. Discuss your aldosterone and renin results and any additional testing with a healthcare provider.

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